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physiological evidence of depression

Is there a definitive physiological difference in a depressed person's body, body chemistry, or brain that can be determined as non-normative in comparison with a non-depressed person?

I was diagnosed with a major depression around 20 years ago, which I've never had treated for a whole lot of reasons. I've seen studies recently which indicate untreated depression can cause several physical symptoms as well as cognitive function symptoms. Over the last three years, I have noticed cognitive effects -- I cannot concentrate. I can get lost in my own thoughts in the middle of a conversation, an interesting one, even. I sometimes participate in conversations without being aware I have done so later. I've chalked it up to my existential crisis, but as I'm "feeling" much better about having no personality, I must consider this is not the root cause.

Re: physiological evidence of depression

Hi, Unknown--

I enjoy your posts.

Dr. Robert has some good stuff on his site about depression. Check out this page called Am I Depressed?. You can also use the search box on his site or here at the top of the page to find other material.

Take care,


Re: physiological evidence of depression

Hey, thanks, Doug. :)

Re: physiological evidence of depression

i wouldn't doubt it.
i read recently that it does indeed effect your physiologically.

i've had depression for ten years and my concentration went a long time ago. now i can only concentrate when i'm really interested in something, or actively partaking in something.

there are possible comorbid links or variables too. perhaps bad nutrition, or a natural propensity to 'wander off' into other cognitive experiences. this becomes more acute with depression, where wandering off can, i believe, be a sign of overstimulation and brain exhaustion.

depressed people are often likely the type who possess something called low latent inhibition, which means not being able to filter out all the stimuli from the environment. see wiki for that.

you may be a 'highly sensitive person' which means your neurology is markedly different from others, and depression is often a by-product for them folk.

sorry though, don't have any pictures or graphs regarding how depression changes the brain.
just my two cents